Tumor Angiogenesis and Anti-angiogenic Therapy
نویسندگان
چکیده
منابع مشابه
Tumor angiogenesis and anti-angiogenic therapy.
Anti-angiogenic therapy is an anti-cancer strategy that targets the new vessels that grow to provide oxygen and nutrients to actively proliferating tumor cells. Most of the current anti-cancer reagents used in the clinical setting indiscriminately target all rapidly dividing cells, resulting in severe adverse effects such as immunosuppression, intestinal problems and hai...
متن کاملBiomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy
Tumor angiogenesis has been identified to play a critical role in tumor growth and tumor progression, and is regulated by a balance of angiogenic and anti-angiogenic cytokines. Among them VEGF (vascular endothelial growth factor) and its signaling through its receptors are of crucial relevance. Inhibition of VEGF signaling by monoclonal antibodies or small molecules (kinase inhibitors) has alre...
متن کاملAngiogenesis and Anti-Angiogenic Therapy in Gastric Cancer
Gastric cancer is one of the most frequent malignancies worldwide. Despite improvements in diagnosis and therapy, the overall prognosis remains poor. In the last decade, several anti-angiogenic drugs for cancer treatment have been approved and lately also introduced to gastric cancer treatment. While the initial trials focused only on unresectable or metastatic cancer, anti-angiogenic treatment...
متن کاملBiological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer
The creation of new blood vessels from existing ones, which is a mechanism called "angiogenesis", is essential in cancer to supply cancerous growth. Moreover, the development and the progression of the tumor and its metastases are the result of an efficient vascular response. Cancer cells release and activate different angiogenic growth factors and their receptors in the tumor microenvironment ...
متن کاملStudies of anti-angiogenic protein variants and screening of candidate tumor angiogenesis markers using Biacore systems
VD4 ++++ +++++ ++++ +++ In order to grow, solid tumors depend on the generation of new blood vessels to supply rapidly proliferating tumor cells with nutrients in a process termed angiogenesis. Angiogenesis requires an intricate network of signals between tumor cells, vascular endothelial cells (ECs) and the surrounding interstitium. Vascular endothelial growth factor (VEGF) and its receptors a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2012
ISSN: 0022-9717,1880-1293
DOI: 10.2302/kjm.61.47